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KMID : 0985420080300020273
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Laboratory Medicine and Quality Assurance
2008 Volume.30 No. 2 p.273 ~ p.277
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Evaluation of the Tosoh HLC-723 G8 HbA1c Autoanalyzer
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Kwon Ae-Rin
Park Ji-Young
Kim Jae-Seok
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Abstract
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Background: We evaluated overall performance and analysis time of newly developed HLC-723 G8 (Tosoh corp., Tokyo, Japan) HbA1c autoanalyzerwhich utilizes cation-exchange HPLC method.
Methods: Linearity, precision, correlation with Variant II Turbo (Bio-Rad Laboratories, Hercules, CA, USA), analysis time, labile HbA1c (L-A1c) separation ability and stability of refrigerated sample at 4degrees C were evaluated.
Results: HLC-723 G8 showed good linearity between HbA1c 4.9-12.0% range (R2=0.9995). Within-run and total imprecision (CVs) were less than 1.0%. Correlation with Variant II Turbo and L-A1c separation ability were excellent. Analysis time per sample took 1.0 min. Stability of refrigerated sample at 4degrees C for at least 21 days was good.
Conclusion: HLC-723 G8 showed good analytical performance and its rapid analysis time enables us to support outpatient diagnosis of diabetic patients efficiently.
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KEYWORD
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HbA1c, Ion-exchange HPLC, Tosoh HLC-723 G8
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